Cd137 Pathway: Immunology and Diseases: Chen, Lieping

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CD137 is closely related to CD27, OX40, and CD30. It is up-regulated on mouse and human T cells upon activation. 2 It has long been recognized as a costimulatory molecule for T cells. TNFRSF9 / 4-1BB / CD137 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses.

CD137 is a member of the tumor necrosis factor receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule. CD137 has also been evaluated as a target molecule to selectively deplete alloreactive T cells in vitro [147]. Compared with other activation-induced antigens, CD137 showed a superior performance based on a consistently low baseline expression and a rapid upregulation following alloantigen stimulation.

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To determine whether CD137 is a potential therapeutic target for enhancing NK cell function, NK cells were first activated to express CD137 by their exposure to EGFR-expressing cancer cells and cetuximab. Recombinant Human CD137 Protein (Met1-Gln186) ECD 10041-H08H with a fusion His Tag, is expressed in HEK293 Cells. With high purity, high biological activity, high stability, and other superior features, you can use this Human CD137 protein for relevant bioassay and related research.

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137A and 137C showed weaker binding affinity than the other Fabs, making them suitable for the generation of the bispecific antibody. CD137 Antibody (BBK-2) is a monoclonal anti-CD137 antibody that detects human CD137 by WB, IP, IF and FCM. CD137 (4-1BB, TNFRSF9) is increasingly recognized as a pow-erful inducer of antitumor immune responses. The potency of CD137 co-stimulation in enabling the immune system to elimi-nate tumors has been documented in a wide plethora of murine tumor models including mastocytoma, sarcoma, colon carci- CD137 is a potent costimulatory receptor. Several agonistic anti‐CD137 antibodies are currently in clinical trials for tumor immunotherapy. Soluble forms of CD137 (sCD137) are generated by differential splicing and antagonize the activities of membrane‐bound CD137 (mCD137) and of therapeutic CD137 agonists.

In fact, these cells express various TCRs that are specific for The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137.
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Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. 2019-11-08 2020-10-20 CD137 is a 39 kD transmembrane protein also known as 4-1BB.

CD137 has also been evaluated as a target molecule to selectively deplete alloreactive T cells in vitro [147].
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LAG-3. HVEM. CD27. CD137.

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Compare (max 4) (7) Recombinant. CD137 Imported

Information which has been imported from another database using automatic procedures.

Automatic assertion inferred from database entries i CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family. CD137 is expressed on activated T and B cells, NK cells, monocytes and follicular dendritic cells. CD137 protein is expressed by a select group of hematolymphoid tumors, including classical Hodgkin lymphoma, T-cell and NK/T-cell lymphomas, and follicular dendritic cells neoplasms.

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CD137 is a member of the tumor necrosis factor ( TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). It is of interest to immunologists as a co-stimulatory immune checkpoint molecule. 4-1BB (CD137) is a costimulatory member of the tumor necrosis factor receptor superfamily that is upregulated on activated T cells, NK cells, NKT cells, and monocytes. 4-1BB is also expressed on Tregs and DCs. CD137 is a kind of costimulatory molecule that mediates T cell activation, which regulates the activity of immune cells in a variety of physiological and pathological processes.

The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis (2). CD137 helps regulate the activation of many immune cells, including CD4(+) T cells, CD8(+) T cells, dendritic cells, and natural killer cells. CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.